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Trucker's Knuckles refers to a severe case of multiple, external anal hemorrhoids that are raging and irritated and have a thrombosed clot under the skin causing a hard, painful lump appearing like the knuckles on a hand. Trucker's Knuckles often occur regularly to those individuals employed in long haul, over the road, driving professions.
Stan: Hey Frank. Are you heading on that haul from Chicago to L.A?
Frank: Yea and not looking forward to it.

Stan: Why?

Frank: I got the worst case of Trucker's Knuckles. Take a look. (Drops pants).
Stan: Holy Shit. Looks like a tiny fist down there. Better get some salve before you hit the road.
by Eaton Holgoode April 15, 2014
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