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Oh, that's nasty 

A common catchphrase used by Cleveland Brown from Family Guy.
*Quagmire and Cleveland are at the pool*
Quagmire: *Takes a leak in the pool*
Cleveland: Oh, that's nasty

Thats Nasty 

Something that is excellent or great. It is used as a good thing, not saying someone or something is disgusting. Nasty is now good
Teacher: If you fuck me i'll give you an A

Student: Thats Nasty!