The saying originated in the movie top gun, when Maverick requests a fly-by, and is denied by the commanding officer.

It was later quoted by David Spade in a 7-up commercial, and has also been used in a few other less reputable media segments.

Basically, it just means no. The phrase Ghost Rider eludes to the pilot's alias, and is an illusion to the comic book character Ghost Rider (though I don't think that is significant).
Can I have pickles on that sub?

That's a negative Ghost Rider.
by 4n0nym0u5! March 10, 2011
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The act of using a sleeping males hand to mastubate with until they wake up. At which point you slap them in the face and yell "negative ghost rider".
Danny decided to give jim a negative ghost rider.
by KWilfong1 March 18, 2016
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Where some 40 year old 80’s obsessive mid-life crisis going through clownshoe turns no into 18 letters (without spaces).
Tyrone: Have you gotten my shoes yet?

Mom: Negative ghost rider

Tyrone: 😑

Mom: Hey honey have you cashed the check yet?

Dad: Negative ghost rider
by wulfyyyyy October 15, 2019
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