a phrase used when you are leaving a place in a hurry due to a potentially dangerous situation
"Man, it looks like this storm is coming in fast. The news projected possible hail and tornadoes."

"Well then I better take my cheese and run, because I don't mess with tornadoes."
by cheeseguy24 November 11, 2022
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An slang Aussie fishing term used to describe fishing in the Murray for Cod and hoping the fish takes the bait and runs with the hook.
Bit quiet on the river today Scotty, hope one will take the cheese and run with it soon.
by Aussie fisho October 8, 2018
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