TFiU!

1. The Future is Useless!
2. When there is no hope left.

Guy 1: Hey, did you apply for college?
Guy 2: Nope, TFiU!

by Jack Minor April 9, 2008

TFIU

1. The Fuck Is Up
2. The act of frustration towards a situation, which one does not clearly understand.

Guy 1: (Walks in on girlfriend sleeping with best friend)
Guy 1: TFIU!
Guy 2: Umm....

by Matteo Ivan July 28, 2011