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Like "Stop it 5" or "Stop it, man" it means "stop that crazy, ridiculous, fucked up thing you're saying" -- with some added flourish. And like the "5" in Stop it 5," the "B" may once have referred to the Bloods street gang, or just may just be short for "blood."

Stop it B is also a popular catchphrase used by comedian Felonious Munk.
"Stop it B... You ain't all that, and none o' those shorties are interested in your broke ass."

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I think I'm gonna vote for Michelle Bachmann. them crazy eyes is sexy.

Just stop it B... You are not that crazy...
Stop it B by YidYetti August 15, 2011
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You take the bomb to B site and plant it. Make sure you do not stop running till you get there. 

You take the bomb to B site and plant it. Make sure you do not stop running till you get there. RUSH B CYKA BLYAT

holy christ thats the worst thing ive ever heard stop it or youre gonna make my ears bleed 

OWSHIT OWSHIT OWSHIT EARS BLEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEED
get the point, yes yes?

Niggas Hating Like A Chain Reaction So Call It A Crumbled Raigeki For Cowards, Full-Stop Because "'Raigeki'" Means ""Thank You'" 

Niggas Hating Like A Chain Reaction So Call It A Crumbled Raigeki For Cowards, Full-Stop Because "'Raigeki'" Means ""Thank You'"
Niggas Hating Like A Chain Reaction So Call It A Crumbled Raigeki For Cowards, Full-Stop Because "'Raigeki'" Means ""Thank You'"