Heroin and crystal meth.

As opposed to heroin and coke.
I can’t afford an 8ball of coke after buying a brick of H, so I’m gonna have to grab a point of meth and do a poor mans speedball
by Brwneyedgrl1985 December 22, 2018
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On a stormy day or night with thunder and lightning impress your friends with this exhilarating party maneuver. 1) Do a shot of your favorite hard booze. (2) Immediately start flying a kite. (3) Once kite is fully in flight, light up a spliff and smoke it while flying the kite. (4) Keep the kite up until said spliff is gone.
This storm is gnarly. Hey! Who wants to do a Ben Franklin Speedball?
by Downtown Dogtown October 25, 2010
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When you mix methamphetamine with dabs.
Dude, me and Timmy did some Granite city speedballs last night, that shuts intense.
by Extrabitchypuddin February 29, 2016
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A poor man's speedball is an alternate version the speedball, a mix of heroin and cocaine, consisting of a mix of NyQuil and a high caffeine Beveridge, usually coffee or a cheap energy drink.
Shitdick: bruv I was gonna go do a few lines but my electric bill cost more than I thought so you best believe I'm rocking that poor man's speedball tonight.

Craig: wouldn't it cost less to just buy weed? Like how is this an economically sound way of getting high, this doesn't make any sense...
by Sauce puppet March 9, 2020
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When you take a Benadryl due to Austin, Texas's incredibly high amount of cedar and oak pollen in the air. But then you have to take a shot of espresso to counteract the inevitable drowsiness. Benadryl is a downer. Caffeine is an upper. That's why it's an Austin speedball.
Dude, I was sneezing all day and my eyes were super bloodshot until I took an Austin speedball.
by bp_austin March 30, 2019
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A combination drug consisting of Vyvanse or Adderall, caffeine, and weed. Often used to enter a hyper-focused state of mind while taking a slight edge off of the stress. Also used almost daily by severely ADHD stoners to function as an adult without collapsing into a pit of despair.
“Holy fuck dude are you okay? You look like you’re tweaking.”

“Yeah bro I’m totally fine, I just took a Silicon Valley Speedball so I could knock this project out. I also rearranged my office, flossed four times to get the blood out of my teeth, and drew this dragon fighting a hundred duck-sized horses. I’m chillin’.”
by Erect Cactus July 19, 2022
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A combination of Dayquil plus Nyquil.

(Courtesy of EIS)
A: Did you hear about Justin?

B; No, why?
A: He got all fucked up on a mormon speedball and streaked through a police station singing "funky town",,,
B: Fucking Mormon Speedballs, Not even once.
by neuro_nick January 3, 2017
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