Also 6, 2, and Even. A phrase referring to horseraces, where those numbers on a horse indicated that that horse was most likely to win, so it was the safest horse to bet on. Outside of horseracing, the phrase claims what is most likely going to happen.
Joe: Hey, did you hear about the George leaving his girl?

Philip: Yeah, but I wouldn't worry too much. Six, Two, and Even he'll have another girl in three days.
by Vintage Translator February 2, 2018
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