Sally McSlutticus Share definition Flag An insult directed at a female who is considered to be a slut based on her reputation for being/acting loose. "Did you guys see the new girl; she was all over Joe, she was acting like a big Sally McSlutticus." Sally McSlutticus by Angelic_Sherry June 11, 2006 0 0 Get merch Get the Sally McSlutticus mug. Buy Now — $32.95 See more merch