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After having sex with someone for the first time, the inevitable thought that you may possibly have just received some strange STD, even if safe sex was practiced.

STD Paranoia can also lead to the misinterpretation of something harmless as symptoms of an STD.
John: "Remember that girl i told you I hooked up with about a week ago? I think she gave me an STD, I have this patch of red skin on my dick!"
Craig: "Sounds like a classic case of STD Paranoia bro, don't worry, it happens to everyone. Just put some moisturizer on that shit and you're golden."
by 132299 April 16, 2009
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