Used synonymously with "my condolences". A way of showing deep appreciation or concern for a homie.
"My mom forgot to tell me my great grandma died"

"Oh shit, prayers up bro"
by Vanessa mills August 2, 2020
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When you throw your prayers up in runescape
"Bruh those vennies be raggin you, prayers up"
"ty homie"
by September 7, 2021
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