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The sinking, sad feeling that one gets after finishing a really good, funny, or original anime. This feeling may also be extended to TV shows, music, books, and video games.
Anime nerd 1: Damn, dude! I just finished Death Note and i can't stop feeling dead inside!

Anime nerd 2: Sounds like a case of Post-Anime Depression to me!
by Nick December June 29, 2011
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