When someone is annoying the utter fuck out of you or generally being a dick you may have to initiate the pick a hand. Simply ask the asshole to pick between one of your two extended hands with no further explanation, when the douchebag picks a hand you proceed to smack the shit out of them with their chosen prize. Note that if the son of a bitch is aware of the game they will most likely not pick a hand due to the obvious implications.
That piece of shit tried to hit on my girlfriend! I'm going to ask him to pick a hand.

Did you just say pineapples don't belong on pizza? Pick a hand.
by tokeshed January 22, 2018
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after a jenkin drop'n'pop, taking your handful of semen, and picking up a piece of poop in the other hand, then with both hands behind your back, approaching someone and telling them to pick a hand. Placing the chosen item in his/her hand, and slapping them in the face with the other. Not to be performed on friends.
A man was murdered this weekend after performing a ROCK BOTTOM - pick a hand.
by James Delaware November 10, 2010
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A racist slur for a thief that's directed towards a black individual or meant to insult someone as such.
Get your cotton picking hands off of that TV, boy!
by Mark Alfano June 24, 2015
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