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The combination of the two most disgusting substances, menstrual blood (PERIod) and shit (pOOP).
"Dude did you see the toilet in the second stall? It was clogged with so much perioop I almost vommed all over the floor!"

"EW this perioop was the worst thing I ever saw AND smelled!"
by theclitnextdoor March 07, 2011
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