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To be rendered permanently stupid as a result of excessive Botox injections. Often used in conjunction with the adjective "reided," which refers to a syndrome in which ordinary declarative statements are converted into idiotic gibberish as a result of too much exposure to herbicides.
Lydia's final trip to the plastic surgeon went terribly wrong, leaving her pelosified.

"We lost another public official to pelosification," Jill exclaimed as she dropped the hypodermic syringe.

Nancy was both reided and pelosified, rendering her unable to function in adult society.
by david1225 February 21, 2010
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When a confused individual starts speaking gibberish and totally believes they are saying something of value
That asshat has no idea what he is even saying - he is so pelosified.
by Isheet Madroorz June 18, 2017
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