to totally loose your shit esp. when speaking on a phone to your former significant other. characterized by the sustained inability to speak without screaming as though your genitals were ablaze. Sometimes also characterized by being out of breath and breathing heavily into the phone like a crazed gorilla.
dude #1: did you hear that tape of Mel Gibson and his lady friend?
dude 2: yup. dude sounded fucking nuts, over the edge, like he went mel-loco
dude 2: yup. dude sounded fucking nuts, over the edge, like he went mel-loco
by oilcan905 July 14, 2010
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Mel-loco
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