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It stands for Mainstream For The Underground. The phrase was coined by James at Cyber-FM

All Artists start out as MFTU at one time or another. With a local following fan base, a spread of the word, and hard work, some get to swipe the special pen, sign a deal, and go on to play all over the world putting out albums for us all to hear!
Person 1: Do you MFTU?
Person 2: Yeah, I had playing earlier, they had a few MFTU artists playing!
by MJK94 November 08, 2012
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Apr 15 Word of the Day
to take an unfortunate loss and turn of events.
"last night took an L, but tonight I bounce back" - Big Sean (2017)
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by urbansammy January 20, 2017
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