There’s two meanings, one is ok backwards and the other is short for knock out.
John: did you know k.o. Is ok backwards?

Shantiya: I friggin K.O.ed that guy when we had a fight!
by Nightmare_m u f f i n June 7, 2022
Get the K.O. mug.
A fat Dutch Masters blunt. Usually smoked before bed, and will typically make you fall asleep fast. A.k.a "K"nocking you "O"ut. Usually smoked by G ass people
"Bro spark that K.O. Dutch so we can slump"
"Roll up a K.O. Dutch before we go to bed"
by OTF_300 December 17, 2017
Get the k.o. dutch mug.