A mouse that lives in someones vagina (along with other STDs) that says "No" and closes the vagina if it doesnt want sex. Joe, the mouse usually wants sex because he has low self esteem.
by Bitchz July 09, 2014
A euphemistic way to reference Joe Biden's famous open mike reference to the Health Care Reform bill. Used in polite conversation with those current on political events.
by lwray March 24, 2010