IND2P (Ind2P, Indanyl-2-Propanone), is an intermediate in the synthesis of IAP (IndanylAminoPropane) and IMAP (IndanylMethylAminoPropane). It is made by reacting IndanylMethyl Magnesium Chloride (Ind-MeMgCl) and Acetonitrile in diethyl ether, followed by acid work-up. IND2P is also made by reacting Indanyl Bromide (Ind-Br) with ethyl acetoacetate using sodium ethoxide, hydrochloric acid, and a Copper Iodide (CuI) catalyst. Indanyl-2-Propanone can react with methylamine using aluminum galinstan amalgam to synthesize IndanylMethylAminoPropane (IMAP).
Tony: I synthesized IMAP by reacting IND2P with methylamine in a reductive amination using aluminum galinstan.
by CognitiveFuel August 16, 2023