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The University of Hoss or "Hoss U" is a made up collage, and is used to refer to people who are not going to collage. It most commonly refers to bigger muscular boys who are dumb or not very bright. And implies they are going to Hoss U to presue a degree in "being a hoss"
Jack: "Charlie is such a Hoss he just plows through their defensive line!"

Dave: "I know! He is defiantly committing to Hoss University"
by hinsdale kid April 30, 2015
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