A gun; a sidearm; something which allows you to protect your bodily integrity.

Used extensively by rappers from Queens.
I got the Guard-U for you and you (meaning I got a gun, dont Fuck wit me!) Source: Noreaga hailing from Queens Bridge Projects (or in Noreaga vernacular: Lef Rac City Queens!)
by Ryan E. Bates August 11, 2005
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A nickname for The University of Arizona, referring to the men's basketball program's consistent development and output of quality NBA guards, especially point guards. The name was first applied by CBS sports analyst Van Coleman and is now in common usage.
Steve Kerr,
Damon Stoudamire,
Mike Bibby,
Jason Terry,
Gilbert Arenas,
Richard Jefferson,
Andre Iguodala,
Jerryd Bayless,
just to name a few of the Point Guard U's alumni.
by KaiTing November 16, 2010
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