Gizzweed Share definition Flag A loser. Someone who will never suceed in life simply based on the fact that they suck in everyway. Friend: Hey do you see that guys with the shaved legs?Me: Yeah what a gizzweed Gizzweed by jonjonson October 30, 2011 0 0 Get merch Get the Gizzweed mug. Buy Now — $32.95 See more merch