doofitis Share definition Flag The condition when the memory of a doofus is cloudy due to inflammation caused from stupidity AJ- "I wasn't positive.. my memory is a lil cloudy."Jacqui- "Cloudy from what?? Doofitis?" doofitis by doofitis January 14, 2011 0 0 Get merch Get the doofitis mug. Buy Now — $32.95 See more merch