Top definition
The act of wondering if you should eat something, that might cause some gastrointestinal problems later.
Mike:Hmmm should i eat the 5 buck box from taco bell now...im going on a date in about 4 hours, i dont want to have to repaint her toilet. I will go with a homemade chicken salad instead.

Rajieen: yeah you wouldn't want to get some bad Colon karma for later.
by mr bonkers113 September 24, 2011
Get the mug
Get a Colon Karma mug for your mama Julia.