A polite way of proposing your needs of using the wash room!
Girl: Hey I have to answer the call of nature!
Girl 1: Can I come
Girl 2: Let's go
The rest of the girls: Ya! LET'S GO TOGETHER!!!
by StickyFingers27 July 15, 2021
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an evacuation of waste matter from the body.

Often described as:
Taking a piss or taking a shit
Bob: Excuse me I need to answer the call of nature.
*Bob gets up and walks away*
Jim: (to George) Where is Bob going?
George: To take a piss he said.
Jim: You sure he didn't mean take a shit
George: I could give a fuck less Jim.
by WizeKracker April 14, 2014
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When someone responds to the call of nature during a work-related conference call. People must take great care to mute their phone during said act or risk professional embarrassment.
You were extremely quiet during the conference call?
Yeah dude, Conference Call of Nature
by crc5654 September 24, 2011
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