Top definition
A sickness.When you like a girl a lot, but are too much of a pussy to ask her out for 3-4 years. And because you are so much of a bitch you let her slip into the arms of other guys (Nice Going).You have had 2 girlfriends since you started liking her, but they didn't last because 1 was a cheater and 1 was just not fun. The girls name usually begins with an H.
DeAngelo: "Hey John,I haven't seen you for years! How's it going?"
John: "Not well man, I just got back from the doctor, and it turns out I have Bryce Syndrome for Snooki"
DeAngelo: "DAAMMMMNNN, you're screwed"
by Theycallhimtheprophet October 10, 2011
Get the mug
Get a Bryce Syndrome mug for your grandma Julia.