1. When a person"s worldly problems involving time or money, not to be confused with emotional/spiritual issues, reach a point where the brain can no longer function without intense consternation and worry.
1. "I am not making enough money, and I am going to run out soon, my brain-is-on-fire."

2. "Ernest can't be reached right now, he is having business troubles, his brain-is-on-fire."

3. "We need to have this finished by week's end, however, it will take much longer, our brains-are-on-fire."
by View Man February 4, 2012
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Basically a brain fire is when you go sicko mode but in a retarded way like u go stupid crazy and turnt up to 💯
Omfg yooooo this man's having a brain fire let's gooooo "chant" brain fire brain fire brain fire!!!
by Kingkenzie October 13, 2019
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