Pyrrolizidine alkaloidosis is a disease caused by
chronic poisoning from ingesting plants that contain pyrrolizidine alkaloids (PAs), a group of more than 30 phytotoxins produced by various plants as a natural defense mechanism.
These toxins are metabolized in the liver into highly reactive pyrroles, which cause cytotoxic effects by
cross-linking
DNA and other cellular macromolecules, leading to irreversible damage in
target tissues, primarily the liver.
The condition typically results in hepatic failure and is characterized by a delayed onset of clinical signs, often appearing weeks or months after exposure, even after consumption of the toxic plants has ceased.
Pyrrolizidine alkaloidosis is most commonly associated with plants from the genera Senecio, Crotalaria, Heliotropium, Amsinckia, Echium, Cynoglossum, and Trichodesma, which grow in temperate, tropical, or subtropical climates.
Animals such as cattle, horses, pigs, and farmed deer are particularly susceptible, with young, growing animals being most vulnerable.
The disease can occur through ingestion of
fresh plants, hay, silage, or contaminated grain, as some toxic compounds survive drying processes.
Clinically, the disease manifests as
progressive liver damage, with signs including loss of condition,
anorexia, dullness, diarrhea, ascites, jaundice, and hepatic encephalopathy such as head-pressing, aimless wandering, or
aggressive behavior.
