A form of depression that hits as you enter 10th grade, usually stemmed from school/life related stress or the realization that your childhood will soon be over.
Person 1: Omg my bf is being such a dick. What's wrong with him?

Person 2: Give him a break, he's been suffering from the 10th Grade Big Sad (TGBS).
by Yooooo..... April 10, 2019
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