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Debbie Downsyndrome 

A person who is always down and it a bad mood, and puts others in bad moods as well. Usually is in a bad mood from being ugly or gettin made fun of.
person 1: "Tough fish"
person 2: "Heis, stop being Debbie Downsyndrome for 5 min"

down's symdrome 

down's symdrome:A condition resulting from a chromosomal abnormality characterized by mental retardation and such physical signs as slanted eyes, flattened facial features, short status and tendency toward obesity. this is down's symdrome .
you are a fuckin' mongo!
you got down's symdrome or summit?
down's symdrome by nikki101 June 23, 2006

Double Downsyndrome 

When two adults with down syndrome have a kid who also has down syndrome. Jokingly the kid would have twice as many extra chromosomes.
Double DownSyndrome
Doctor: No, you two shouldn't try for kids!
Dad: Kids? Kids!!
Kid: Nnyaa!