Thot Knot Share definition Flag A group of 3 or more thots who are clumped together, making a knot in your path. Guy 1: "Aw damn, my girlfriends caught in a thot knot!" Guy 2: "Shit bro, best untangle that shit fast!" Thot Knot by ThotKnotUntangler May 31, 2018 Get the Thot Knot mug.