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Metaphorically: When you get utterly fucked over by something that is beyond your control.

Literally: When playing Nazi Zombies on Call of Duty Black Ops and you get the HS10 from the mystery box.
1. Dude, Inception just HS10'd my mind.

2. a) Okay I'm gonna use the mystery box....Fuck the HS10

b) HA you just got HS10'd

Related: Black Ops Call of Duty Nazi Zombies
HS10'd by Durzo Blint December 15, 2010
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hs1enthusiast2.0 

The best account on tik tok and my favorite mutual ever
Who’s that they are so funny!!?
that’s hs1enthusiast2.0!!