effidol Share definition Flag A metaphorical drug which allows a person to stop being affected as much over a negative or stressful event, essentially allowing them to think 'eff it all.' We lost the game pretty badly, so I took some effidol. effidol by Amy_S March 24, 2017 0 0 Get merch Get the effidol mug. Buy Now — $32.95 See more merch
