The Yayo Share definition Flag A nickname for the city of Miami, FL. Originated from "M-I-AYO", another nickname given to the city. Person 1: "Ayo you tryna slide to the yayo today?"Person 2: "Naw bruh, i gotta bond my lil bruh" The Yayo by Zambookie January 4, 2012 0 0 Get merch Get the The Yayo mug. Buy Now — $32.95 See more merch