5 loko Share definition Flag 5 hour energy, any 4loko flavor of juice (grape, fruit punch, etc.) and vodka. Due to the recent ban on 4lokos, 5 loko has been gaining popularity in the 425 area. 5 loko by Jbay8 November 29, 2010 0 0 Get merch Get the 5 loko mug. Buy Now — $32.95 See more merch