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panties in a bunch 

1. When a person overreacts to a trifling insult or barb, or to a joke.

2. When someone acts in an anal-retentive manner, and makes a big fuss out of a relatively minor problem.
1. Don't get you're panties all in a bunch, he doesn't mean it.

2. It's not that big of a problem, don't get your panties all in a bunch, it's going to be okay.
panties in a bunch by teh pope January 18, 2005
Related Words

red panties 

When a woman wears red panties for a night out by herself or with the "girls"and leaves her man at home, she's looking to get laid/have sex with someone else.
"I found nude pics on my boyfriend's IPhone from some nasty bitch, fuck it...I'm going to the club. Where are my red panties?"
red panties by k1centurion March 30, 2016

loose pantie 

dude: " i wouldn't like to fuck her"

dude 2: " that loose pantie"
loose pantie by spider333 February 13, 2009
Next to the greatest thing on Earth. ;)
Josh: "I love panties, but they keep coming between me and what I love most."
panties by SweetBlue October 6, 2005

keep your panties on 

An expression used primarily in the southern U.S. to tell someone who is acting impatiently to calm down.
Person #1: Ya'll best be fixin' to get them fences up 'fore I get mind to tan your hide!
Person #2: I reckon you keep your panties on, darlin', or you gon' get madder than a wet hen!

partied out 

Effects of too much partying/drinking/nights on the lash etc
Person 1: "You look rough"
Person 2: "Yeah, am partied out!"
partied out by Lynzy July 24, 2006