For a person to engage in the very excessive consumption of a variety of intoxicating substances such as alcohol, MDMA and cocaine, among others, within a short time period and, invariably, to the detriment of an individuals normal daily routine and responsibilities the following day.
"Dude, last night was off the wall. I didn't mean to get right on it but didn't go to bed till 7am and was 2 hours late for work."
"Hahaha, bro.... you look like shit. Got right on it again last night, didn't you?"