butt-piller Share definition Flag n. one who engages in the act of placing pills or other tabs such as ecstasy in their rectum. Hey frank, did sasquatch just shove a hit of ecstasy up his ass?yeah, he's a total butt-piller. butt-piller by frankie capone November 28, 2013 0 0 Get merch Get the butt-piller mug. Buy Now — $32.95 See more merch