LadyDuke Share definition Flag A courteous and refined lady who will not hesitate to put her dukes up. Alissa is the nicest, most caring, and selfless lady you'll ever meet. However, if you piss her off, she will fuck you up. She is a real LadyDuke! LadyDuke by DeDuke March 21, 2021 0 0 Get merch Get the LadyDuke mug. Buy Now — $32.95 See more merch