significize Share definition Flag To make significant; to cause to become relevant or prominent. Pronounced as either sig-NIF-ih-kyz or sig-NIF-ih-size. Winning an Oscar significized Marisa Tomei's career. Or, at least it should have... significize by G. Thomas December 17, 2006 0 0 Get merch Get the significize mug. Buy Now — $32.95 See more merch