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Derogatory term made by a resident of a First Nations native living on a reserve. The word originates from "reserve" and "lesbian", where "Rezbian" would be a lesbian woman living on a reserve.

Also, "Rezbian" can be described as the way Scooby Doo would say "lesbian".
"This reserve has no rezbians."
"Hey, you know how Scooby Doo would say 'lesbian'?"
"How?"
"Rezbian."
Rezbian by Josh Courtoreille June 8, 2007
Related Words
A female avatar in a virtual world, played by a real-world male, or to a lesser extent, a straight female, for the purpose of soliciting lesbian cybersex. Comes from combining "rezzed" and "lesbian".
He played a rezbian to satisfy his fantasies; too bad the chick he hooked up with was also a rezbian.
Rezbian, the opposite of Ghey/Gay. People would use the term "Ghey/Gay" as a way of saying something sucks. I have used the term Rezbian as the say way or using as a name, either way works.
"Dude, that's so rezbian."

"You're so rezbian."
Rezbian by Annaden April 13, 2010
Movement for being open about your inner Rezbian. Most Rezbians can be found either flexing biceps or checking out Jenny Chams new post
MuM, I tHiNk IM rEZBiaN”
Rezbian by Yannake Dunne June 1, 2019
A red headed lezbian.. A combination of red head and lezbian
Lindsey Lohan is a rezbian
rezbian by RonniA January 5, 2009

Rezzbian 

An individual whose emotional, romantic, and sexual energies are geared towards musical artist Rezz.
Wow, that guy Jake is obsessed with Rezz, perhaps he's a rezzbian.
Rezzbian by angel_voices July 22, 2017