LSHYDFO 

Laughing So Hard Your Dick Falls Off.
It happens when you look at multiple mems at the same time.

Jim looked at mems and began LSHYDFO and had to go to emergency room!

LSHYDFO by GhostNinja0007 October 5, 2018

LSHMDFO 

Laughing so hard my dick fell of

Can technically be used for both male/female sentences.

“What’s wrong Little Johnny?”
“I was LSHMDFO!”
“Glad you liked my joke.”

LSHMDFO by Subscribe to pewdiepie. December 7, 2020

LSHYTFOAMSB

Laughing So Hard Your Tongue Falls Out And Makes Squid Babies

(Used in place of LOL, LMAO, ROFL...)

(Similar to LSHMTFOAMSB; Laughing So Hard My Tongue Fell Out And Made Squid Babies)

Friend 1: I've got a really funny knock knock joke. But you have to start.

Friend 2: Ok. Knock Knock.

Friend 1: Who's there?

Friend 2: *awkward silence*

Friend 1: Hahahahahahahahahaha. I just laughed so hard my tongue fell out and made squid babies (LSHYTFOAMSB)

LSHYTFOAMSB by ORANGELEMONADE October 18, 2012

LSHMDFO 

Acronym- Laughing So Hard My Dingers Fell Out

Old Woman: LSHMDFO!
Son: What, mom?!
Old Woman: Laughing so hard my dingers fell out!
Son: TMI!

LSHMDFO by N00000000000b June 6, 2010