The term defines the cause of why things go wrong or something breaks when there is no real explanation. The term may also be used to refer to a gullible human being. Someone who believes anything you say.
Person 1: "Dude I don't understand why this motor won't turn over."
Person 2: "Because Plotkin"
Person 1: "I can't believe that I listened to him. I knew something was wrong."
Person 2: "You're a Plotkin bro."