Where using idiotic phrases in reference to intelligent work causes the work to be destroyed.
By using the 'pwned' in reference to a potentially major scientific breakthrough you've actually made AIDS mutate to become airborne and highly contagious.
Another case of the Nantucket Principle at work was when the Wright brothers tried their first airplane prototype. Just before they were going to do their first test flight Orville said something to the effect of 'We are going to codfloddle this strumpet!' which caused Bernoulli's principle to completely change, setting flight back many years.