Definitions by Will S.

P.I. 

Pussy-Itis, Puss-Itis, Pussy Itch. Being whiny and bitchy over a small, often imaginary injury.

Kid 1: Owww! You hurt my finger, I don't wanna play anymore.
Kid 2: Dude, you've got a major case of P.I.

P.I. by Will S. April 19, 2006