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Definitions by S. D. Plissken

To make a mistake. The term results from the step-by-step transitioning as follows:

1. Fucked up
2. Muffed up
3. Merfed up

Also, a slurring of "motherfucker" which can be used in polite public.
After erasing a large data file from his computer, Tony's friend said, "Dude, you merfed up big time!"
Merf by S. D. Plissken March 25, 2005