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Definitions by Rob Richards

syphed up 

A person who has contracted a considerable number of sexually transmitted diseases.

A person who hits a nasty chick from the back and contracts all her diseases.
Joe: "hey man I heard you hit that nasty chick that works at Denny's"
Rob R: "Yeah I hit that shit and now I'm all syphed up"
syphed up by Rob Richards December 10, 2006