A Female that gets around. A slut, tramp, whore, etc... Originating from the classic song "Run around Sue" by singer Dion in 1961, the song clearly explains a lose woman that "took my heart and ran around, with every man in down". It is a more classy way to call a girl a Slut.
I don't think you want to take that girl serious she's a Run around sue.
That Run Around Sue has smashed half the city.