(verb) - to contract a long term sexually transmitted disease like herpes, HPV, or HIV.
1. "I got my test results back the other day
and they said shit ain't lookin too good for me
turns out some dumb fuckin bitch got me marked!" -Twiztid "Sex, Drugs, Money & Murder"
2. Yo, man don't fuck wit that bitch over there... she marked my homie wit that HIV shit. She be shootin up and shit.